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KMID : 0388219940010020200
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Journal of the Korean Rheumatism Association
1994 Volume.1 No. 2 p.200 ~ p.212
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Immunoclobulin Gene Repertoire in Rheumatoid Synovium as a Model for Autoimmune Disease
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Abstract
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Objective :
@EN To gain insights into structural characteristics of immunoglobulin kappa chain repertoire exressed in the inflammed synovium of rheumatoid arthritis (RA), we analyzed Vk transcirpts expressed in the synovium of a patient with longstanding RA
and
compared to those expressed in the PBLs of RA and normal controls.
@ES methods :
@EN RT-PCR was done to amplify kappa chain transcripts from RA synovial lymphocytes and the cDNA sequences were compared to those from PBL of RA patient or normal control.
@ES Results :
@EN kappa chain repertoire from RA patient'sd synovial lymphocytes or PBL revealed increased somatic mutation and unusually long complementarity determining region (CDR) 3 compared to normal control.
@ES Conclusion :
@EN These changes in kappa chain repertoire in RA patient are suggesting that the antibody repertoire expressed in the synovium or PBL is unique and may be related with systemic dysregulation of B cell development.
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KEYWORD
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